The research program of QuantFung is summarised in the figure below.

Work package one (WP 1) deals with the discovery of secondary metabolite clusters. In work package two (WP2), the activation of secondary metabolite clusters which are not expressed under standard laboratory conditions or which derive from metagenomics approaches are examined. The quantification of secondary metabolites with the goal to identify and produce them in industrially established hosts including Penicillium chrysogenum, Aspergillus niger, and Saccaromyces cerevisae is researched in work package three (WP3). These three work packages merge into work package four (WP4) which focusses on the bioactivity testing of identified secondary metabolites as putative products.

 All research projects are presented in the tables below. PhD students (ESRs) will look at the following topics:

Research Topics Host
De novo design of artificial genetic circuits for filamentous fungi Technische Universität Berlin
Identification and characterisation of novel secondary metabolite  clusters by synthetic biology University of Göttingen
Penicillium chrysogenum as a generic host for the production of secondary metabolites University of Groningen
Synthetic biology of antibiotics production University of Groningen
Discovery of secondary metabolites and bioactive compounds in filamentous fungi Technical University of Denmark
Quantitative physiology of secondary metabolite production in filamentous fungi Technical University of Denmark
Assembly and annotation of genomic sequences for fungal secondary metabolite production Kiel University
Advanced fermentation techniques for the cultivation of filamentous fungi University of Debrecen
Optimization of fungal platforms for the production of secondary metabolites Chalmers University
Discovery of Streptomycetes induced fungal secondary metabolite Formation Hans-Knöll-Institute
Targeted expression of secondary metabolite gene clusters in Penicillium chrysogenum DSM

 

and Post-Docs (ERs) at:

Research Topics Host
Integrated network analysis of transcriptomics and proteomics data Technische Universität Berlin
Exploration of dimorphic switches from filamentous growth to single Hülle cells as tool for synthetic biology University of Göttingen
Synthetic biology of antibiotics production DSM
Fungal secondary metabolites, a perspective from metabolomics Chalmers University